HORDB

ID: hor002055
Uniprot ID: Q9NDE7
Protein name: Insulin A chain
Gene name: PIN
Organism: Aplysia californica (California sea hare)
Family: Insulin family
Source: Animal
Expression: Expressed in the central region of the cerebral ganglia mostly within the F and C clusters.
Disease: NA
Comments: NA
Taxonomy: Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: EASGSITCECCFNQCRIFELAQYCRLPDHFFSRIS
Length: 35(105-139)
Propeptide: MSKFLLQSHSANACLLTLLLTLASNLDISLANFEHSCNGYMRPHPRGLCGEDLHVIISNLCSSLGGNRRFLAKYMVKRDTENVNDKLRGILLNKKEAFSYLTKREASGSITCECCFNQCRIFELAQYCRLPDHFFSRISRTGRSNSGHAQLEDNFS
Signal peptide: MSKFLLQSHSANACLLTLLLTLASNLDISLA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002055_AF2.pdb

hor002055_ESM.pdb

Mass:	468227	Formula:	C176H265N49O53S5
Absent amino acids:	KMVW	Common amino acids:	C
pI:	5.6	Basic residues:	4
Polar residues:	13	Hydrophobic residues:	11
Hydrophobicity:	0	Boman Index:	-6512
Half-Life:	1 hour	Half-Life Yeast:	30 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	61.43
Instability Index:	2169.43	Extinction Coefficient cystines:	1740
Absorbance 280nm:	51.18

PubMed ID: 10479677
Title: Insulin prohormone processing, distribution, and relation to metabolism in Aplysia californica.